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| Id: | 21492
| | Autor: | Rotberg, A. | | Título: | The reading of the lepromin test.
| | Fonte: | Int. J. Lepr;7(2):161-166, Apr.-Jun. 1939. tab.
| | Resumo: | The present system of reading the leprolim test was established arbitrarily, and the findings have been related to the different forms of leprosy, the immunological characteristics of which are still uncertain. From this combination of unknown factors much confusion may arise. For example, of 194 nodular cases 74 gave "positive" reactions that could evidently have no immunological or prognostic significance. Studying the evolution of the reaction in two very distinct groups of cases, nodular and tuberculoid, with undoubtedly opposite conditions of immunity, the author points out the essential distinctive features of the reactions typical of these forms of the disease. In the nodular form the test is negative: there is no reaction, or only a small papular one, due to nonspecific factors, which reaches its maximum before the fourth or fifth day, seldom is larger than 5 mm., and may persist until the fourth week. In the tuberculoid form the true positive reaction occurs: a nodular lesion, often suppurating, usually belated in appearing, of progressive evolution, generally reaching its maximum from the second to the sixth week, seldom less than 5 mm. in diameter in the fourth week. The dimensional criterion of positivity is not sufficient, and the test must be performed by trained observers familiar with the clinical signs. Even so, it is necessary to admit a large group of doubtful reactions, of indefinite aspect and borderline dimensions (4-6 mm. diameter). Recognition of doubtful groups permits not only avoiding error of reporting reactions, but also avoids possible faults due to different antigenic values of different lots of lepromin, the standardization of which still presents a problems. (AU).
| | Descritores: | HANSENIASE
HANSENIASE/clas
ANTIGENO DE MITSUDA/clas
ANTIGENO DE MITSUDA/uso diag
ANTIGENO DE MITSUDA/isol
| | Meio Eletrônico: | - .
| | Localização: | BR191.1 |
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